1y4b Summary

pdbe.org/1y4b
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T-To-T(High) quaternary transitions in human hemoglobin: betaW37H deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch blood microparticlesearch membranesearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch heme bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch positive regulation of cell deathsearch protein heterooligomerizationsearch bicarbonate transportsearch oxygen transportsearch small molecule metabolic processsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch
B, D (P68871) blood microparticlesearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch oxygen transportsearch regulation of blood pressuresearch small molecule metabolic processsearch blood coagulationsearch bicarbonate transportsearch renal absorptionsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch transportsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch nitric oxide transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxidation-reduction processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch