1y46 Summary

pdbe.org/1y46
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PDB entry 1y46 (supersedes 1a0v)

T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) hemoglobin complexsearch extracellular exosomesearch endocytic vesicle lumensearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch oxygen transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch response to hydrogen peroxidesearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch
B, D (P68871) extracellular regionsearch cytosolsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch endocytic vesicle lumensearch blood microparticlesearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch oxygen transportsearch regulation of blood vessel sizesearch nitric oxide transportsearch renal absorptionsearch small molecule metabolic processsearch protein heterooligomerizationsearch regulation of blood pressuresearch blood coagulationsearch bicarbonate transportsearch receptor-mediated endocytosissearch oxidation-reduction processsearch platelet aggregationsearch response to hydrogen peroxidesearch transportsearch hydrogen peroxide catabolic processsearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin bindingsearch oxygen bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch