1y45 Summary

pdbe.org/1y45
spacer

T-To-T(high) quaternary transitions in human hemoglobin: betaP36A deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain Not available
Homo sapienssearch 99% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch membranesearch cytosolic small ribosomal subunitsearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of cell deathsearch transportsearch
B, D (P68871) iron ion bindingsearch haptoglobin bindingsearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen bindingsearch metal ion bindingsearch heme bindingsearch hemoglobin complexsearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch extracellular vesicular exosomesearch oxygen transportsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch blood coagulationsearch bicarbonate transportsearch small molecule metabolic processsearch regulation of blood pressuresearch renal absorptionsearch nitric oxide transportsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch oxidation-reduction processsearch protein heterooligomerizationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch