1y35 Summary

pdbe.org/1y35
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T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.12 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen transportsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch small molecule metabolic processsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch extracellular regionsearch hemoglobin complexsearch membranesearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch haptoglobin-hemoglobin complexsearch
B, D (P68871) heme bindingsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch iron ion bindingsearch oxygen transportsearch nitric oxide transportsearch response to hydrogen peroxidesearch regulation of blood pressuresearch transportsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch platelet aggregationsearch small molecule metabolic processsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch blood coagulationsearch oxidation-reduction processsearch protein heterooligomerizationsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch