1y35 Summary

pdbe.org/1y35
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T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.12 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch protein heterooligomerizationsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) protein heterooligomerizationsearch oxidation-reduction processsearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch response to hydrogen peroxidesearch nitric oxide transportsearch transportsearch blood coagulationsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch regulation of blood vessel sizesearch platelet aggregationsearch positive regulation of cell deathsearch small molecule metabolic processsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin bindingsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch