1y31 Summary

pdbe.org/1y31
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T-To-T(High) quaternary transitions in human hemoglobin: betaY35A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.13 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch membranesearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch heme bindingsearch iron ion bindingsearch protein heterooligomerizationsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch oxygen transportsearch small molecule metabolic processsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch
B, D (P68871) endocytic vesicle lumensearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch renal absorptionsearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch blood coagulationsearch platelet aggregationsearch regulation of blood vessel sizesearch oxidation-reduction processsearch regulation of blood pressuresearch nitric oxide transportsearch transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch