1y2z Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) extracellular regionsearch blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch membranesearch cytosolsearch cytosolic small ribosomal subunitsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch haptoglobin bindingsearch metal ion bindingsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch oxygen transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch transportsearch
B, D (P68871) blood microparticlesearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch iron ion bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch hemoglobin bindingsearch renal absorptionsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch platelet aggregationsearch nitric oxide transportsearch oxygen transportsearch oxidation-reduction processsearch transportsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch protein heterooligomerizationsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch