1y22 Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaV33A deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.16 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch iron ion bindingsearch oxygen transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch response to hydrogen peroxidesearch transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch blood microparticlesearch extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch membranesearch endocytic vesicle lumensearch cytosolsearch
B, D (P68871) heme bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch protein bindingsearch hemoglobin bindingsearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch renal absorptionsearch oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch platelet aggregationsearch regulation of blood pressuresearch blood coagulationsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch receptor-mediated endocytosissearch transportsearch nitric oxide transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch