› 1y1z

X-ray diffraction
1.5Å resolution

Crystal structure of the NR1 ligand binding core in complex with ACBC

Released:
DOI: 10.2210/pdb1y1z/pdb
PDB entry 1y1z coloured by chain, front view.
PDB entry 1y1z coloured by chain, side view.
PDB entry 1y1z coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.
Inanobe A, Furukawa H, Gouaux E
Neuron 47 71-84 (2005)
PMID: 15996549

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152906 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35439 (Residues: 394-544, 663-800; Coverage: 31%)
Gene names: Grin1, Nmdar1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand 192 1 x 192
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 41.548Å b: 72.68Å c: 96.614Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.201 0.237
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
24 more

6 mentions without citation

Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.
Zhou et al. (2017)
5 more