1y1a Summary



The structure was published by Blamey, C.J., Ceccarelli, C., Naik, U.P., and Bahnson, B.J., in 2005 in a paper entitled "The crystal structure of calcium- and integrin-binding protein 1: Insights into redox regulated functions" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Calcium and integrin binding 1 (calmyrin).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calcium and integrin binding 1 (calmyrin) Q99828 (9-191) (CIB1_HUMAN)search Homo sapienssearch 96% 183 100%
B Calcium and integrin binding 1 (calmyrin) Q99828 (9-191) (CIB1_HUMAN)search Homo sapienssearch 96% 183 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99828 (9 - 191) Calcium and integrin binding 1 (calmyrin) Homo sapiens

Chain Structural classification (SCOP)
A, B (Q99828) Calmodulin-likesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (Q99828) growth conesearch cell peripherysearch endoplasmic reticulumsearch cytoplasmsearch nucleussearch microtubule organizing centersearch filopodium tipsearch perinuclear region of cytoplasmsearch plasma membranesearch membranesearch extracellular vesicular exosomesearch Golgi apparatussearch cytoskeletonsearch nucleoplasmsearch nucleolussearch neuronal cell bodysearch lamellipodiumsearch neuron projectionsearch cell projectionsearch sarcolemmasearch vesiclesearch ruffle membranesearch centrosomesearch apical plasma membranesearch positive regulation of cell proliferationsearch positive regulation of establishment of protein localization to plasma membranesearch positive regulation of cell migrationsearch response to ischemiasearch positive regulation of protein phosphorylationsearch endomitotic cell cyclesearch cellular response to growth factor stimulussearch positive regulation of ERK1 and ERK2 cascadesearch positive regulation of cell growthsearch negative regulation of microtubule depolymerizationsearch negative regulation of protein phosphorylationsearch negative regulation of megakaryocyte differentiationsearch positive regulation of gene expression involved in extracellular matrix organizationsearch negative regulation of protein kinase B signalingsearch positive regulation of protein serine/threonine kinase activitysearch positive regulation of protein targeting to membranesearch positive regulation of cell-matrix adhesionsearch positive regulation of calcineurin-NFAT signaling cascadesearch negative regulation of cell proliferationsearch cytoplasmic microtubule organizationsearch cellular response to nerve growth factor stimulussearch thrombopoietin-mediated signaling pathwaysearch cellular response to tumor necrosis factorsearch spermatid developmentsearch positive regulation of metalloenzyme activitysearch positive regulation of NF-kappaB transcription factor activitysearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of male germ cell proliferationsearch negative regulation of neuron projection developmentsearch cell adhesionsearch cell cyclesearch platelet formationsearch negative regulation of apoptotic processsearch spermatogenesissearch positive regulation of cell adhesion mediated by integrinsearch angiogenesissearch cellular response to DNA damage stimulussearch cell divisionsearch regulation of cell proliferationsearch regulation of cell divisionsearch positive regulation of substrate adhesion-dependent cell spreadingsearch apoptotic processsearch extrinsic apoptotic signaling pathwaysearch cell differentiationsearch double-strand break repairsearch protein bindingsearch calcium ion bindingsearch protein anchorsearch metal ion bindingsearch Ras GTPase bindingsearch ion channel bindingsearch

Chain InterPro annotation
A, B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch