1y0w Summary

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T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.14 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch hemoglobin complexsearch extracellular regionsearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch membranesearch extracellular exosomesearch cytosolic small ribosomal subunitsearch oxygen transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch receptor-mediated endocytosissearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of cell deathsearch
B, D (P68871) iron ion bindingsearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin complexsearch extracellular exosomesearch extracellular regionsearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch oxygen transportsearch transportsearch renal absorptionsearch regulation of blood vessel sizesearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch regulation of blood pressuresearch protein heterooligomerizationsearch platelet aggregationsearch nitric oxide transportsearch receptor-mediated endocytosissearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch