1y0w Summary

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T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.14 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch oxygen bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch protein bindingsearch metal ion bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch extracellular regionsearch membranesearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch
B, D (P68871) platelet aggregationsearch oxygen transportsearch receptor-mediated endocytosissearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch blood coagulationsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch renal absorptionsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch regulation of blood pressuresearch transportsearch oxygen bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch iron ion bindingsearch hemoglobin bindingsearch cytosolsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch