1y0t Summary

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T-to-T(High) Quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (1 test set)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.14 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch cytosolic small ribosomal subunitsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch membranesearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch oxygen transportsearch response to hydrogen peroxidesearch transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch
B, D (P68871) heme bindingsearch oxygen transporter activitysearch metal ion bindingsearch protein bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch iron ion bindingsearch oxygen bindingsearch peroxidase activitysearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch extracellular regionsearch blood microparticlesearch renal absorptionsearch protein heterooligomerizationsearch blood coagulationsearch oxygen transportsearch regulation of blood vessel sizesearch small molecule metabolic processsearch oxidation-reduction processsearch transportsearch bicarbonate transportsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch platelet aggregationsearch regulation of blood pressuresearch positive regulation of cell deathsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch