› 1y0s

X-ray diffraction
2.65Å resolution

Crystal structure of PPAR delta complexed with GW2331

Released:
DOI: 10.2210/pdb1y0s/pdb
PDB entry 1y0s coloured by chain, front view.
PDB entry 1y0s coloured by chain, side view.
PDB entry 1y0s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype.
Takada I, Yu RT, Xu HE, Lambert MH, Montana VG, Kliewer SA, Evans RM, Umesono K
Mol Endocrinol 14 733-40 (2000)
PMID: 10809235

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 272 amino acids
Theoretical weight: 31.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 170-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand IOD 11 x IOD
Ligand 331 2 x 331
Ligand B7G 2 x B7G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 39.356Å b: 94.523Å c: 96.492Å
α: 90° β: 97.92° γ: 90°
R-values:
R R work R free
0.21 0.21 0.261
Expression system: Escherichia coli

Quick links

Citations

12 review citations

PPAR delta: a dagger in the heart of the metabolic syndrome.
Barish et al. (2006)
11 more

4 mentions without citation

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.
Xie et al. (2009)
3 more