1y0j Summary


Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction

The structure was published by Liew, C.K., Simpson, R.J.Y., Kwan, A.H.Y., et al., Matthews, J.M., Crossley, M., and Mackay, J.P., in 2005 in a paper entitled "Zinc fingers as protein recognition motifs: Structural basis for the GATA-1/Friend of GATA interaction" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Erythroid transcription factor and Zinc-finger protein ush.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Erythroid transcription factor P17679 (200-243) (GATA1_MOUSE)search Mus musculussearch < 90% 46 84%
B Zinc-finger protein ush Q9VPQ6 (202-235) (USH_DROME)search Drosophila melanogastersearch < 90% 36 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P17679 (200 - 243) Erythroid transcription factor Mus musculus
Q9VPQ6 (202 - 235) Zinc-finger protein ush Drosophila melanogaster

Chain Structural classification (SCOP) Sequence family (Pfam)
A Erythroid transcription factor GATA-1search GATA zinc fingersearch
B C2HC fingersearch C2H2-type zinc fingersearch

Chain ID Molecular function (GO) Biological process (GO)
A (P17679) zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch
B (Q9VPQ6) nucleic acid bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Zinc finger, GATA-typesearch Zinc finger, NHR/GATA-typesearch
B Zinc finger, C2H2search Zinc finger, C2H2-likesearch