1y0d Summary

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PDB entry 1y0d (supersedes 1dsh)

T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-141) (HBA_HUMAN)search Homo sapienssearch 98% 140 100%
C Hemoglobin alpha chain P69905 (2-141) (HBA_HUMAN)search Homo sapienssearch 98% 140 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 141) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) response to hydrogen peroxidesearch oxygen transportsearch transportsearch bicarbonate transportsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch peroxidase activitysearch heme bindingsearch oxygen transporter activitysearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch cytosolsearch
B, D (P68871) oxygen transportsearch protein heterooligomerizationsearch renal absorptionsearch oxidation-reduction processsearch positive regulation of cell deathsearch transportsearch bicarbonate transportsearch nitric oxide transportsearch blood coagulationsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch regulation of blood pressuresearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch heme bindingsearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch iron ion bindingsearch extracellular regionsearch blood microparticlesearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch