1y0c Summary

pdbe.org/1y0c
spacer

T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 140) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin complexsearch extracellular regionsearch membranesearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch blood microparticlesearch oxygen transportsearch transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch
B, D (P68871) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch hemoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch oxygen transportsearch platelet aggregationsearch transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch nitric oxide transportsearch small molecule metabolic processsearch renal absorptionsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch blood coagulationsearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch