1y0c Summary

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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 140) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen bindingsearch hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch cytosolic small ribosomal subunitsearch blood microparticlesearch membranesearch protein heterooligomerizationsearch transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch oxidation-reduction processsearch
B, D (P68871) oxygen transporter activitysearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch metal ion bindingsearch heme bindingsearch haptoglobin bindingsearch iron ion bindingsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch bicarbonate transportsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch platelet aggregationsearch transportsearch positive regulation of cell deathsearch oxygen transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch renal absorptionsearch oxidation-reduction processsearch protein heterooligomerizationsearch regulation of blood pressuresearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch