1y0a Summary

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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 140) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) metal ion bindingsearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch membranesearch haptoglobin-hemoglobin complexsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxygen transportsearch transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch transportsearch bicarbonate transportsearch oxidation-reduction processsearch renal absorptionsearch oxygen transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch regulation of blood pressuresearch platelet aggregationsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch blood coagulationsearch response to hydrogen peroxidesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch