1y0a Summary

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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 140) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch heme bindingsearch oxygen transporter activitysearch oxygen bindingsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch oxygen transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch extracellular regionsearch cytosolic small ribosomal subunitsearch membranesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch blood microparticlesearch
B, D (P68871) protein bindingsearch haptoglobin bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch oxygen bindingsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch regulation of blood pressuresearch oxygen transportsearch oxidation-reduction processsearch platelet aggregationsearch transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch nitric oxide transportsearch regulation of blood vessel sizesearch blood coagulationsearch bicarbonate transportsearch response to hydrogen peroxidesearch blood microparticlesearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch