1y0a Summary

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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-140) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 140) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) extracellular regionsearch membranesearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch response to hydrogen peroxidesearch bicarbonate transportsearch oxygen transportsearch transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch peroxidase activitysearch haptoglobin bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch response to hydrogen peroxidesearch bicarbonate transportsearch receptor-mediated endocytosissearch oxygen transportsearch renal absorptionsearch regulation of blood pressuresearch small molecule metabolic processsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch blood coagulationsearch platelet aggregationsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch transportsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch