1y01 Summary


Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin

The structure was published by Feng, L., Gell, D.A., Zhou, S., et al., Weiss, M.J., Mackay, J.P., and Shi, Y., in 2004 in a paper entitled "Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Alpha-hemoglobin stabilizing protein and Hemoglobin alpha chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-hemoglobin stabilizing protein Q9NZD4 (1-102) (AHSP_HUMAN)search Homo sapienssearch 90% 102 87%
B Hemoglobin alpha chain P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 88%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9NZD4 (1 - 102) Alpha-hemoglobin stabilizing protein Homo sapiens
P69905 (1 - 142) Hemoglobin alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q9NZD4) Alpha-hemoglobin stabilizing protein AHSPsearch Alpha-hemoglobin stabilizing proteinsearch PF09236: Alpha-haemoglobin stabilising proteinsearch
B (P69905) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q9NZD4) cytoplasmsearch hemoglobin complexsearch protein foldingsearch hemoglobin metabolic processsearch hemopoiesissearch protein stabilizationsearch hemoglobin bindingsearch unfolded protein bindingsearch
B (P69905) extracellular regionsearch cytosolsearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch transportsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha-haemoglobin stabilising proteinsearch
B Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch