1y01 Summary

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Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin

The structure was published by Feng, L., Gell, D.A., Zhou, S., et al., Weiss, M.J., Mackay, J.P., and Shi, Y., in 2004 in a paper entitled "Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Alpha-hemoglobin stabilizing protein and Hemoglobin alpha chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-hemoglobin stabilizing protein Q9NZD4 (1-102) (AHSP_HUMAN)search Homo sapienssearch 90% 102 87%
B Hemoglobin alpha chain P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 88%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9NZD4 (1 - 102) Alpha-hemoglobin stabilizing protein Homo sapiens
P69905 (1 - 142) Hemoglobin alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q9NZD4) Alpha-hemoglobin stabilizing protein AHSPsearch Alpha-hemoglobin stabilizing proteinsearch PF09236: Alpha-haemoglobin stabilising proteinsearch
B (P69905) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q9NZD4) protein foldingsearch hemoglobin metabolic processsearch protein stabilizationsearch hemopoiesissearch cytoplasmsearch hemoglobin complexsearch hemoglobin bindingsearch unfolded protein bindingsearch
B (P69905) oxygen transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch membranesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch

Chain InterPro annotation
A Alpha-haemoglobin stabilising proteinsearch
B Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch