1xzu Summary

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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaD94G deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.16 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch cytosolsearch oxygen bindingsearch protein bindingsearch iron ion bindingsearch haptoglobin bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch small molecule metabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch oxygen transportsearch bicarbonate transportsearch transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch
B, D (P68871) hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch heme bindingsearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch platelet aggregationsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch small molecule metabolic processsearch renal absorptionsearch blood coagulationsearch regulation of blood pressuresearch regulation of blood vessel sizesearch positive regulation of cell deathsearch nitric oxide transportsearch receptor-mediated endocytosissearch transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch