1xz7 Summary

pdbe.org/1xz7
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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaR92A deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch peroxidase activitysearch heme bindingsearch haptoglobin bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch iron ion bindingsearch small molecule metabolic processsearch oxidation-reduction processsearch oxygen transportsearch bicarbonate transportsearch transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch membranesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch
B, D (P68871) heme bindingsearch protein bindingsearch oxygen bindingsearch oxygen transporter activitysearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch platelet aggregationsearch nitric oxide transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch oxygen transportsearch positive regulation of cell deathsearch transportsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch bicarbonate transportsearch blood coagulationsearch response to hydrogen peroxidesearch regulation of blood pressuresearch protein heterooligomerizationsearch cytosolsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch