1xz5 Summary

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T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaL91A deoxy low-salt

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.11 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch peroxidase activitysearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch iron ion bindingsearch heme bindingsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch membranesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch response to hydrogen peroxidesearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxygen transportsearch transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxidation-reduction processsearch
B, D (P68871) heme bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch metal ion bindingsearch endocytic vesicle lumensearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch protein heterooligomerizationsearch renal absorptionsearch oxygen transportsearch blood coagulationsearch small molecule metabolic processsearch regulation of blood vessel sizesearch bicarbonate transportsearch regulation of blood pressuresearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of cell deathsearch transportsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch