1xww Summary

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Crystal Structure of Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6 Angstrom Resolution

The structure was published by Zabell, A.P., Schroff, A.D., Bain, B.E., Van Etten, R.L., Wiest, O., and Stauffacher, C.V., in 2006 in a paper entitled "Crystal structure of the human B-form low molecular weight phosphotyrosyl phosphatase at 1.6-A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Low molecular weight phosphotyrosine protein phosphatase. This molecule has the UniProt identifier P24666 (PPAC_HUMAN)search. The sample contained 157 residues which is 99% of the natural sequence. Out of 157 residues 157 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Low molecular weight phosphotyrosine protein phosphatase P24666 (2-158) (PPAC_HUMAN)search Homo sapienssearch 99% 157 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24666 (2 - 158) Low molecular weight phosphotyrosine protein phosphatase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24666) Rossmann foldsearch PF01451: Low molecular weight phosphotyrosine protein phosphatasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24666) phosphoprotein phosphatase activitysearch acid phosphatase activitysearch protein tyrosine phosphatase activitysearch phosphatase activitysearch protein bindingsearch non-membrane spanning protein tyrosine phosphatase activitysearch hydrolase activitysearch cytoplasmsearch extracellular vesicular exosomesearch cytoplasmic side of plasma membranesearch peptidyl-tyrosine dephosphorylationsearch protein dephosphorylationsearch

Chain InterPro annotation
A Protein-tyrosine phosphatase/arsenate reductasesearch Protein-tyrosine phosphatase, low molecular weight, mammaliansearch Protein-tyrosine phosphatase, low molecular weightsearch Phosphotyrosine protein phosphatase I superfamilysearch