1xws Summary

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Crystal Structure of the human PIM1 kinase domain

A publication describing this structure is not available. The depositing authors are Knapp, S.search; Debreczeni, J.search; Bullock, A.search; von Delft, F.search; Sundstrom, M.search; Arrowsmith, C.search; Edwards, A.search; Guo, K.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN)search. The sample contained 313 residues which is < 90% of the natural sequence. Out of 313 residues 271 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene serine/threonine-protein kinase Pim-1 P11309 (92-404) (PIM1_HUMAN)search Homo sapienssearch 100% 313 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (92 - 404) Proto-oncogene serine/threonine-protein kinase Pim-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P11309) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P11309) protein phosphorylationsearch negative regulation of apoptotic processsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch