1xvp Summary

pdbe.org/1xvp
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crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO

The structure was published by Xu, R.X., Lambert, M.H., Wisely, B.B., et al., Moore, L.B., Willson, T.M., and Moore, J.T., in 2004 in a paper entitled "A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, and nuclear receptor coactivator 1 isoform 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Retinoic acid receptor RXR-alpha P19793 (227-462) (RXRA_HUMAN)search Homo sapienssearch 98% 236 100%
C Retinoic acid receptor RXR-alpha P19793 (227-462) (RXRA_HUMAN)search Homo sapienssearch 98% 236 100%
B Orphan nuclear receptor NR1I3 Q14994 (103-352) (NR1I3_HUMAN)search Homo sapienssearch < 90% 246 100%
D Orphan nuclear receptor NR1I3 Q14994 (103-352) (NR1I3_HUMAN)search Homo sapienssearch < 90% 246 100%
E nuclear receptor coactivator 1 isoform 1 Q15788 (685-697) (NCOA1_HUMAN)search Homo sapienssearch < 90% 13 92%
F nuclear receptor coactivator 1 isoform 1 Not available
Synthetic < 90% 13 92%
G nuclear receptor coactivator 1 isoform 1 Not available
Synthetic < 90% 13 92%
H nuclear receptor coactivator 1 isoform 1 Not available
Synthetic < 90% 13 92%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (227 - 462) Retinoic acid receptor RXR-alpha Homo sapiens
Q14994 (103 - 352) Orphan nuclear receptor NR1I3 Homo sapiens
Q15788 (685 - 697) nuclear receptor coactivator 1 isoform 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P19793) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch
B, D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
E, F, G, H Steroid receptor coactivatorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P19793) steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch zinc ion bindingsearch DNA bindingsearch nucleussearch
B, D (Q14994) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch thyroid hormone receptor activitysearch nucleussearch

Chain InterPro annotation
A, C Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B, D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
E, F, G, H Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch