› 1xvk

X-ray diffraction
1.26Å resolution

X-ray structure of an Echinomycin-(GCGTACGC)2 complex

Released:
DOI: 10.2210/pdb1xvk/pdb
PDB entry 1xvk coloured by chain, front view.
PDB entry 1xvk coloured by chain, side view.
PDB entry 1xvk coloured by chain, top view.
Source organism: Streptomyces echinatus
Primary publication:
Structures of complexes between echinomycin and duplex DNA.
Cuesta-Seijo JA, Sheldrick GM
Acta Crystallogr D Biol Crystallogr 61 442-8 (2005)
PMID: 15805599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-114832 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
ECHINOMYCIN Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 809 Da
Source organism: Streptomyces echinatus
5'-D(*GP*CP*GP*TP*AP*CP*GP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Streptomyces echinatus
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand QUI 2 x QUI
2 modified residues:
Ligand DSN 2 x DSN
Ligand MVA 2 x MVA

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6322
Unit cell:
a: 39.183Å b: 39.183Å c: 79.89Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 not available 0.221
Expression system: Not provided

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Citations

8 review citations

Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.
Dawson et al. (2007)
7 more

4 mentions without citation

Indirect readout in drug-DNA recognition: role of sequence-dependent DNA conformation.
Araúzo-Bravo et al. (2008)
3 more