› 1xtn

X-ray diffraction
2.2Å resolution

crystal structure of CISK-PX domain with sulfates

Released:
DOI: 10.2210/pdb1xtn/pdb
PDB entry 1xtn coloured by chain, front view.
PDB entry 1xtn coloured by chain, side view.
PDB entry 1xtn coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX).
Xing Y, Liu D, Zhang R, Joachimiak A, Songyang Z, Xu W
J Biol Chem 279 30662-9 (2004)
PMID: 15126499

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Sgk3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 14.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9ERE3 (Residues: 7-126; Coverage: 24%)
Gene names: Cisk, Sgk3, Sgkl
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21212
Unit cell:
a: 114.139Å b: 45.002Å c: 59.202Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.24
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Lang et al. (2006)
9 more

5 mentions without citation

Translation of the phosphoinositide code by PI effectors.
Kutateladze TG. (2010)
4 more