1xra Summary

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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE

The structure was published by Takusagawa, F., Kamitori, S., Misaki, S., and Markham, G.D., in 1996 in a paper entitled "Crystal structure of S-adenosylmethionine synthetase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of S-ADENOSYLMETHIONINE SYNTHETASE. This molecule has the UniProt identifier P0A817 (METK_ECOLI)search. The sample contained 383 residues which is 100% of the natural sequence. Out of 383 residues 377 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-ADENOSYLMETHIONINE SYNTHETASE P0A817 (2-384) (METK_ECOLI)search Escherichia coli K-12search 100% 383 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A817 (2 - 384) S-ADENOSYLMETHIONINE SYNTHETASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0A817) S-adenosylmethionine synthetasesearch GMP Synthetase; Chain A, domain 3search PF00438: S-adenosylmethionine synthetase, N-terminal domainsearch, PF02772: S-adenosylmethionine synthetase, central domainsearch, PF02773: S-adenosylmethionine synthetase, C-terminal domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P0A817) S-adenosylmethionine biosynthetic processsearch one-carbon metabolic processsearch S-adenosylmethionine cyclesearch cytosolsearch cytoplasmsearch identical protein bindingsearch methionine adenosyltransferase activitysearch ATP bindingsearch transferase activitysearch metal ion bindingsearch magnesium ion bindingsearch protein bindingsearch nucleotide bindingsearch potassium ion bindingsearch

Chain InterPro annotation
A S-adenosylmethionine synthetasesearch S-adenosylmethionine synthetase, N-terminalsearch S-adenosylmethionine synthetase, central domainsearch S-adenosylmethionine synthetase, C-terminalsearch S-adenosylmethionine synthetase, conserved sitesearch S-adenosylmethionine synthetase superfamilysearch