1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P37840) cytoplasmsearch extracellular regionsearch nucleussearch plasma membranesearch membranesearch lysosomesearch actin cytoskeletonsearch cell junctionsearch axonsearch growth conesearch fibrilsearch synapsesearch cytosolsearch rough endoplasmic reticulumsearch cytoplasmic vesicle membranesearch mitochondrionsearch inclusion bodysearch ribosomesearch platelet alpha granule membranesearch intracellular membrane-bounded organellesearch nuclear outer membranesearch perinuclear region of cytoplasmsearch Golgi apparatussearch synaptic vesiclesearch terminal boutonsearch cytoskeletonsearch cell cortexsearch axon terminussearch regulation of dopamine secretionsearch protein destabilizationsearch synaptic vesicle endocytosissearch negative regulation of apoptotic processsearch calcium ion homeostasissearch negative regulation of monooxygenase activitysearch dopamine biosynthetic processsearch cellular response to copper ionsearch regulation of macrophage activationsearch synaptic transmissionsearch regulation of acyl-CoA biosynthetic processsearch oxidation-reduction processsearch negative regulation of serotonin uptakesearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of neurotransmitter secretionsearch adult locomotory behaviorsearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch positive regulation of inositol phosphate biosynthetic processsearch cellular response to oxidative stresssearch response to iron(II) ionsearch synaptic vesicle transportsearch regulation of neuronal synaptic plasticitysearch response to lipopolysaccharidesearch positive regulation of endocytosissearch negative regulation of norepinephrine uptakesearch negative regulation of thrombin receptor signaling pathwaysearch agingsearch negative regulation of neuron apoptotic processsearch positive regulation of synaptic transmissionsearch negative regulation of dopamine metabolic processsearch negative regulation of histone acetylationsearch regulation of long-term neuronal synaptic plasticitysearch behavioral response to cocainesearch regulation of glutamate secretionsearch response to cocainesearch synapse organizationsearch response to drugsearch cellular response to fibroblast growth factor stimulussearch negative regulation of microtubule polymerizationsearch mitochondrial membrane organizationsearch regulation of phospholipase activitysearch extracellular fibril organizationsearch dopamine metabolic processsearch dopamine uptake involved in synaptic transmissionsearch cell deathsearch synaptic transmission, dopaminergicsearch positive regulation of protein serine/threonine kinase activitysearch neutral lipid metabolic processsearch regulation of locomotionsearch negative regulation of transporter activitysearch negative regulation of protein phosphorylationsearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch regulation of neurotransmitter secretionsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch microglial cell activationsearch response to magnesium ionsearch cellular response to epinephrine stimulussearch receptor internalizationsearch positive regulation of receptor recyclingsearch regulation of neuron deathsearch long-term synaptic potentiationsearch phospholipid metabolic processsearch response to interleukin-1search regulation of excitatory postsynaptic membrane potentialsearch mitochondrial ATP synthesis coupled electron transportsearch response to interferon-gammasearch negative regulation of exocytosissearch fatty acid metabolic processsearch identical protein bindingsearch microtubule bindingsearch kinesin bindingsearch tau protein bindingsearch magnesium ion bindingsearch copper ion bindingsearch phospholipase bindingsearch protein bindingsearch beta-tubulin bindingsearch Hsp70 protein bindingsearch fatty acid bindingsearch calcium ion bindingsearch phospholipase D inhibitor activitysearch dynein bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch phospholipid bindingsearch metal ion bindingsearch enzyme bindingsearch alpha-tubulin bindingsearch histone bindingsearch zinc ion bindingsearch protein domain specific bindingsearch protein N-terminus bindingsearch phosphoprotein bindingsearch oxidoreductase activitysearch ferrous iron bindingsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch