1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P37840) fatty acid bindingsearch phospholipase D inhibitor activitysearch magnesium ion bindingsearch copper ion bindingsearch calcium ion bindingsearch protein bindingsearch phospholipid bindingsearch microtubule bindingsearch ferrous iron bindingsearch zinc ion bindingsearch oxidoreductase activitysearch kinesin bindingsearch enzyme bindingsearch protein domain specific bindingsearch Hsp70 protein bindingsearch histone bindingsearch identical protein bindingsearch alpha-tubulin bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch phospholipase bindingsearch transcription regulatory region DNA bindingsearch dynein bindingsearch metal ion bindingsearch protein N-terminus bindingsearch tau protein bindingsearch beta-tubulin bindingsearch phosphoprotein bindingsearch calcium ion homeostasissearch negative regulation of transcription from RNA polymerase II promotersearch microglial cell activationsearch positive regulation of receptor recyclingsearch negative regulation of protein phosphorylationsearch positive regulation of neurotransmitter secretionsearch synaptic transmission, dopaminergicsearch fatty acid metabolic processsearch neutral lipid metabolic processsearch phospholipid metabolic processsearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch mitochondrial membrane organizationsearch synaptic transmissionsearch agingsearch adult locomotory behaviorsearch response to iron(II) ionsearch regulation of phospholipase activitysearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch regulation of glutamate secretionsearch regulation of dopamine secretionsearch negative regulation of microtubule polymerizationsearch receptor internalizationsearch protein destabilizationsearch response to magnesium ionsearch negative regulation of transporter activitysearch response to lipopolysaccharidesearch negative regulation of monooxygenase activitysearch positive regulation of peptidyl-serine phosphorylationsearch response to interferon-gammasearch cellular response to oxidative stresssearch negative regulation of histone acetylationsearch regulation of locomotionsearch response to cocainesearch dopamine biosynthetic processsearch dopamine metabolic processsearch response to drugsearch mitochondrial ATP synthesis coupled electron transportsearch regulation of macrophage activationsearch positive regulation of apoptotic processsearch negative regulation of apoptotic processsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch extracellular fibril organizationsearch negative regulation of neuron apoptotic processsearch cellular response to fibroblast growth factor stimulussearch positive regulation of endocytosissearch negative regulation of exocytosissearch negative regulation of dopamine metabolic processsearch regulation of neurotransmitter secretionsearch behavioral response to cocainesearch regulation of neuronal synaptic plasticitysearch regulation of long-term neuronal synaptic plasticitysearch synaptic vesicle endocytosissearch synaptic vesicle transportsearch positive regulation of synaptic transmissionsearch synapse organizationsearch regulation of acyl-CoA biosynthetic processsearch positive regulation of release of sequestered calcium ion into cytosolsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch negative regulation of serotonin uptakesearch negative regulation of norepinephrine uptakesearch oxidation-reduction processsearch regulation of excitatory postsynaptic membrane potentialsearch long-term synaptic potentiationsearch positive regulation of inositol phosphate biosynthetic processsearch membrane organizationsearch negative regulation of thrombin receptor signaling pathwaysearch response to interleukin-1search cellular response to copper ionsearch cellular response to epinephrine stimulussearch positive regulation of protein serine/threonine kinase activitysearch regulation of neuron deathsearch negative regulation of mitochondrial electron transport, NADH to ubiquinonesearch positive regulation of glutathione peroxidase activitysearch positive regulation of hydrogen peroxide catabolic processsearch regulation of synaptic vesicle recyclingsearch regulation of reactive oxygen species biosynthetic processsearch regulation of reactive oxygen species metabolic processsearch mitochondrial respiratory chain complex Isearch platelet alpha granule membranesearch extracellular regionsearch nucleussearch nuclear outer membranesearch cytoplasmsearch mitochondrionsearch lysosomesearch rough endoplasmic reticulumsearch Golgi apparatussearch cytosolsearch ribosomesearch cytoskeletonsearch plasma membranesearch cell cortexsearch synaptic vesiclesearch actin cytoskeletonsearch membranesearch inclusion bodysearch cell junctionsearch axonsearch growth conesearch cytoplasmic vesicle membranesearch terminal boutonsearch fibrilsearch intracellular membrane-bounded organellesearch axon terminussearch synapsesearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch