1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P37840) identical protein bindingsearch protein bindingsearch tau protein bindingsearch zinc ion bindingsearch copper ion bindingsearch metal ion bindingsearch ferrous iron bindingsearch oxidoreductase activitysearch phospholipid bindingsearch histone bindingsearch phosphoprotein bindingsearch magnesium ion bindingsearch phospholipase bindingsearch protein domain specific bindingsearch Hsp70 protein bindingsearch kinesin bindingsearch beta-tubulin bindingsearch phospholipase D inhibitor activitysearch protein N-terminus bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch microtubule bindingsearch dynein bindingsearch transcription regulatory region DNA bindingsearch fatty acid bindingsearch calcium ion bindingsearch enzyme bindingsearch alpha-tubulin bindingsearch long-term synaptic potentiationsearch positive regulation of protein serine/threonine kinase activitysearch negative regulation of microtubule polymerizationsearch regulation of phospholipase activitysearch response to cocainesearch regulation of macrophage activationsearch dopamine uptake involved in synaptic transmissionsearch regulation of neuron deathsearch extracellular fibril organizationsearch negative regulation of mitochondrial electron transport, NADH to ubiquinonesearch negative regulation of transcription from RNA polymerase II promotersearch cellular response to fibroblast growth factor stimulussearch regulation of acyl-CoA biosynthetic processsearch synaptic transmissionsearch negative regulation of transporter activitysearch synaptic transmission, dopaminergicsearch mitochondrial ATP synthesis coupled electron transportsearch dopamine biosynthetic processsearch receptor internalizationsearch synaptic vesicle transportsearch positive regulation of receptor recyclingsearch response to interleukin-1search microglial cell activationsearch response to drugsearch fatty acid metabolic processsearch positive regulation of glutathione peroxidase activitysearch response to interferon-gammasearch negative regulation of exocytosissearch regulation of reactive oxygen species metabolic processsearch negative regulation of neuron apoptotic processsearch positive regulation of neurotransmitter secretionsearch synapse organizationsearch response to magnesium ionsearch cellular response to epinephrine stimulussearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch regulation of glutamate secretionsearch regulation of long-term neuronal synaptic plasticitysearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch regulation of dopamine secretionsearch regulation of neuronal synaptic plasticitysearch cellular response to copper ionsearch regulation of reactive oxygen species biosynthetic processsearch positive regulation of hydrogen peroxide catabolic processsearch neutral lipid metabolic processsearch regulation of locomotionsearch negative regulation of serotonin uptakesearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of apoptotic processsearch regulation of excitatory postsynaptic membrane potentialsearch cellular response to oxidative stresssearch phospholipid metabolic processsearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch synaptic vesicle endocytosissearch positive regulation of inositol phosphate biosynthetic processsearch behavioral response to cocainesearch adult locomotory behaviorsearch positive regulation of synaptic transmissionsearch dopamine metabolic processsearch mitochondrial membrane organizationsearch negative regulation of apoptotic processsearch calcium ion homeostasissearch negative regulation of monooxygenase activitysearch protein destabilizationsearch oxidation-reduction processsearch regulation of synaptic vesicle recyclingsearch positive regulation of peptidyl-serine phosphorylationsearch agingsearch negative regulation of protein phosphorylationsearch negative regulation of thrombin receptor signaling pathwaysearch negative regulation of histone acetylationsearch negative regulation of dopamine metabolic processsearch negative regulation of norepinephrine uptakesearch response to lipopolysaccharidesearch positive regulation of endocytosissearch membrane organizationsearch regulation of neurotransmitter secretionsearch response to iron(II) ionsearch cytosolsearch platelet alpha granule membranesearch mitochondrionsearch nucleussearch growth conesearch inclusion bodysearch Golgi apparatussearch cytoplasmsearch membranesearch axon terminussearch synapsesearch extracellular regionsearch cell cortexsearch cytoplasmic vesicle membranesearch fibrilsearch mitochondrial respiratory chain complex Isearch perinuclear region of cytoplasmsearch rough endoplasmic reticulumsearch lysosomesearch plasma membranesearch cell junctionsearch ribosomesearch synaptic vesiclesearch cytoskeletonsearch nuclear outer membranesearch terminal boutonsearch intracellular membrane-bounded organellesearch actin cytoskeletonsearch axonsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch