1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P37840) regulation of dopamine secretionsearch cellular response to copper ionsearch regulation of reactive oxygen species biosynthetic processsearch positive regulation of hydrogen peroxide catabolic processsearch synaptic transmission, dopaminergicsearch negative regulation of apoptotic processsearch calcium ion homeostasissearch negative regulation of monooxygenase activitysearch regulation of excitatory postsynaptic membrane potentialsearch regulation of neuronal synaptic plasticitysearch protein destabilizationsearch synaptic vesicle endocytosissearch positive regulation of inositol phosphate biosynthetic processsearch phospholipid metabolic processsearch cellular response to oxidative stresssearch response to cocainesearch agingsearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch negative regulation of histone acetylationsearch dopamine metabolic processsearch regulation of neurotransmitter secretionsearch positive regulation of peptidyl-serine phosphorylationsearch behavioral response to cocainesearch oxidation-reduction processsearch regulation of synaptic vesicle recyclingsearch negative regulation of serotonin uptakesearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of apoptotic processsearch cellular response to fibroblast growth factor stimulussearch negative regulation of neuron apoptotic processsearch regulation of long-term neuronal synaptic plasticitysearch negative regulation of norepinephrine uptakesearch negative regulation of thrombin receptor signaling pathwaysearch dopamine biosynthetic processsearch membrane organizationsearch response to lipopolysaccharidesearch positive regulation of endocytosissearch adult locomotory behaviorsearch negative regulation of transporter activitysearch synaptic transmissionsearch response to iron(II) ionsearch negative regulation of protein phosphorylationsearch positive regulation of neurotransmitter secretionsearch microglial cell activationsearch positive regulation of protein serine/threonine kinase activitysearch negative regulation of microtubule polymerizationsearch regulation of phospholipase activitysearch extracellular fibril organizationsearch negative regulation of transcription from RNA polymerase II promotersearch regulation of macrophage activationsearch long-term synaptic potentiationsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of mitochondrial electron transport, NADH to ubiquinonesearch synapse organizationsearch response to interferon-gammasearch negative regulation of exocytosissearch fatty acid metabolic processsearch mitochondrial ATP synthesis coupled electron transportsearch synaptic vesicle transportsearch neutral lipid metabolic processsearch negative regulation of dopamine metabolic processsearch positive regulation of synaptic transmissionsearch receptor internalizationsearch positive regulation of receptor recyclingsearch regulation of locomotionsearch response to interleukin-1search positive regulation of glutathione peroxidase activitysearch response to drugsearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch regulation of glutamate secretionsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch regulation of acyl-CoA biosynthetic processsearch regulation of neuron deathsearch mitochondrial membrane organizationsearch response to magnesium ionsearch cellular response to epinephrine stimulussearch cytoplasmsearch plasma membranesearch extracellular regionsearch ribosomesearch intracellular membrane-bounded organellesearch synapsesearch nucleussearch membranesearch growth conesearch lysosomesearch fibrilsearch cytoskeletonsearch synaptic vesiclesearch cytosolsearch mitochondrionsearch inclusion bodysearch axonsearch cell junctionsearch actin cytoskeletonsearch platelet alpha granule membranesearch cytoplasmic vesicle membranesearch nuclear outer membranesearch Golgi apparatussearch rough endoplasmic reticulumsearch cell cortexsearch terminal boutonsearch perinuclear region of cytoplasmsearch mitochondrial respiratory chain complex Isearch axon terminussearch tau protein bindingsearch kinesin bindingsearch protein domain specific bindingsearch Hsp70 protein bindingsearch protein bindingsearch identical protein bindingsearch microtubule bindingsearch magnesium ion bindingsearch copper ion bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch enzyme bindingsearch calcium ion bindingsearch phospholipase D inhibitor activitysearch phospholipase bindingsearch dynein bindingsearch transcription regulatory region DNA bindingsearch fatty acid bindingsearch histone bindingsearch zinc ion bindingsearch phospholipid bindingsearch protein N-terminus bindingsearch alpha-tubulin bindingsearch ferrous iron bindingsearch oxidoreductase activitysearch phosphoprotein bindingsearch beta-tubulin bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch