1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P37840) cytoplasmsearch plasma membranesearch cytosolsearch terminal boutonsearch synapsesearch extracellular regionsearch nucleussearch lysosomesearch nuclear outer membranesearch rough endoplasmic reticulumsearch cell junctionsearch cytoplasmic vesicle membranesearch fibrilsearch actin cytoskeletonsearch growth conesearch intracellular membrane-bounded organellesearch axonsearch inclusion bodysearch mitochondrionsearch platelet alpha granule membranesearch axon terminussearch cytoskeletonsearch synaptic vesiclesearch cell cortexsearch mitochondrial respiratory chain complex Isearch membranesearch ribosomesearch Golgi apparatussearch perinuclear region of cytoplasmsearch cellular response to copper ionsearch regulation of reactive oxygen species biosynthetic processsearch positive regulation of hydrogen peroxide catabolic processsearch dopamine biosynthetic processsearch negative regulation of neuron apoptotic processsearch behavioral response to cocainesearch synaptic vesicle endocytosissearch positive regulation of inositol phosphate biosynthetic processsearch positive regulation of synaptic transmissionsearch synaptic transmissionsearch negative regulation of apoptotic processsearch calcium ion homeostasissearch negative regulation of monooxygenase activitysearch protein destabilizationsearch regulation of long-term neuronal synaptic plasticitysearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of apoptotic processsearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch regulation of excitatory postsynaptic membrane potentialsearch cellular response to oxidative stresssearch mitochondrial ATP synthesis coupled electron transportsearch dopamine metabolic processsearch negative regulation of serotonin uptakesearch positive regulation of peptidyl-serine phosphorylationsearch oxidation-reduction processsearch response to lipopolysaccharidesearch positive regulation of endocytosissearch negative regulation of norepinephrine uptakesearch negative regulation of histone acetylationsearch synaptic vesicle transportsearch regulation of neurotransmitter secretionsearch synapse organizationsearch fatty acid metabolic processsearch negative regulation of thrombin receptor signaling pathwaysearch response to drugsearch long-term synaptic potentiationsearch microglial cell activationsearch synaptic vesicle recyclingsearch cellular response to fibroblast growth factor stimulussearch response to iron(II) ionsearch neutral lipid metabolic processsearch synaptic transmission, dopaminergicsearch negative regulation of transporter activitysearch adult locomotory behaviorsearch negative regulation of mitochondrial electron transport, NADH to ubiquinonesearch extracellular fibril organizationsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of protein serine/threonine kinase activitysearch negative regulation of microtubule polymerizationsearch negative regulation of protein phosphorylationsearch phospholipid metabolic processsearch regulation of neuronal synaptic plasticitysearch regulation of phospholipase activitysearch dopamine uptake involved in synaptic transmissionsearch regulation of acyl-CoA biosynthetic processsearch response to interferon-gammasearch negative regulation of exocytosissearch mitochondrial membrane organizationsearch regulation of dopamine secretionsearch positive regulation of glutathione peroxidase activitysearch negative regulation of dopamine metabolic processsearch response to interleukin-1search regulation of macrophage activationsearch agingsearch regulation of locomotionsearch response to cocainesearch regulation of glutamate secretionsearch positive regulation of receptor recyclingsearch regulation of neuron deathsearch receptor internalizationsearch membrane organizationsearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch response to magnesium ionsearch cellular response to epinephrine stimulussearch positive regulation of neurotransmitter secretionsearch cell deathsearch protein bindingsearch tau protein bindingsearch identical protein bindingsearch Hsp70 protein bindingsearch kinesin bindingsearch microtubule bindingsearch magnesium ion bindingsearch copper ion bindingsearch metal ion bindingsearch protein domain specific bindingsearch phospholipid bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch transcription regulatory region DNA bindingsearch fatty acid bindingsearch calcium ion bindingsearch phospholipase D inhibitor activitysearch enzyme bindingsearch dynein bindingsearch zinc ion bindingsearch phospholipase bindingsearch beta-tubulin bindingsearch histone bindingsearch ferrous iron bindingsearch oxidoreductase activitysearch alpha-tubulin bindingsearch protein N-terminus bindingsearch phosphoprotein bindingsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch