1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P37840) regulation of dopamine secretionsearch positive regulation of synaptic transmissionsearch synapse organizationsearch negative regulation of protein phosphorylationsearch cell deathsearch receptor internalizationsearch response to magnesium ionsearch cellular response to epinephrine stimulussearch response to interleukin-1search positive regulation of receptor recyclingsearch regulation of neuron deathsearch cellular response to fibroblast growth factor stimulussearch regulation of glutamate secretionsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch synaptic vesicle transportsearch response to drugsearch regulation of neuronal synaptic plasticitysearch negative regulation of dopamine metabolic processsearch negative regulation of neuron apoptotic processsearch cellular response to copper ionsearch positive regulation of hydrogen peroxide catabolic processsearch mitochondrial membrane organizationsearch dopamine metabolic processsearch positive regulation of inositol phosphate biosynthetic processsearch agingsearch cellular response to oxidative stresssearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch regulation of neurotransmitter secretionsearch negative regulation of serotonin uptakesearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch protein destabilizationsearch negative regulation of apoptotic processsearch calcium ion homeostasissearch negative regulation of monooxygenase activitysearch phospholipid metabolic processsearch synaptic vesicle endocytosissearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of neurotransmitter secretionsearch oxidation-reduction processsearch negative regulation of histone acetylationsearch synaptic transmissionsearch membrane organizationsearch adult locomotory behaviorsearch microglial cell activationsearch negative regulation of norepinephrine uptakesearch negative regulation of thrombin receptor signaling pathwaysearch response to lipopolysaccharidesearch positive regulation of endocytosissearch regulation of excitatory postsynaptic membrane potentialsearch response to iron(II) ionsearch negative regulation of transporter activitysearch regulation of acyl-CoA biosynthetic processsearch extracellular fibril organizationsearch regulation of locomotionsearch regulation of phospholipase activitysearch neutral lipid metabolic processsearch regulation of macrophage activationsearch fatty acid metabolic processsearch dopamine uptake involved in synaptic transmissionsearch mitochondrial ATP synthesis coupled electron transportsearch positive regulation of protein serine/threonine kinase activitysearch negative regulation of microtubule polymerizationsearch dopamine biosynthetic processsearch behavioral response to cocainesearch synaptic transmission, dopaminergicsearch response to interferon-gammasearch negative regulation of exocytosissearch response to cocainesearch regulation of long-term neuronal synaptic plasticitysearch long-term synaptic potentiationsearch positive regulation of glutathione peroxidase activitysearch cytoplasmsearch nucleussearch cell junctionsearch cell cortexsearch extracellular regionsearch membranesearch cytoskeletonsearch perinuclear region of cytoplasmsearch ribosomesearch cytosolsearch inclusion bodysearch growth conesearch cytoplasmic vesicle membranesearch plasma membranesearch lysosomesearch intracellular membrane-bounded organellesearch synapsesearch fibrilsearch axonsearch actin cytoskeletonsearch nuclear outer membranesearch terminal boutonsearch synaptic vesiclesearch rough endoplasmic reticulumsearch platelet alpha granule membranesearch Golgi apparatussearch mitochondrionsearch axon terminussearch phospholipid bindingsearch protein bindingsearch beta-tubulin bindingsearch identical protein bindingsearch phosphoprotein bindingsearch tau protein bindingsearch Hsp70 protein bindingsearch kinesin bindingsearch protein domain specific bindingsearch magnesium ion bindingsearch copper ion bindingsearch protein N-terminus bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch phospholipase D inhibitor activitysearch dynein bindingsearch fatty acid bindingsearch calcium ion bindingsearch metal ion bindingsearch zinc ion bindingsearch phospholipase bindingsearch alpha-tubulin bindingsearch microtubule bindingsearch enzyme bindingsearch histone bindingsearch ferrous iron bindingsearch oxidoreductase activitysearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch