1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P37840) regulation of dopamine secretionsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch regulation of acyl-CoA biosynthetic processsearch dopamine biosynthetic processsearch synapse organizationsearch negative regulation of serotonin uptakesearch response to cocainesearch positive regulation of protein serine/threonine kinase activitysearch negative regulation of protein phosphorylationsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of thrombin receptor signaling pathwaysearch cellular response to oxidative stresssearch dopamine metabolic processsearch mitochondrial ATP synthesis coupled electron transportsearch positive regulation of neurotransmitter secretionsearch adult locomotory behaviorsearch agingsearch negative regulation of exocytosissearch regulation of phospholipase activitysearch behavioral response to cocainesearch negative regulation of neuron apoptotic processsearch negative regulation of monooxygenase activitysearch microglial cell activationsearch negative regulation of histone acetylationsearch positive regulation of synaptic transmissionsearch extracellular fibril organizationsearch response to drugsearch positive regulation of inositol phosphate biosynthetic processsearch cellular response to fibroblast growth factor stimulussearch negative regulation of dopamine metabolic processsearch synaptic transmission, dopaminergicsearch regulation of neurotransmitter secretionsearch synaptic vesicle endocytosissearch positive regulation of endocytosissearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of release of sequestered calcium ion into cytosolsearch phospholipid metabolic processsearch positive regulation of peptidyl-serine phosphorylationsearch fatty acid metabolic processsearch negative regulation of norepinephrine uptakesearch regulation of neuronal synaptic plasticitysearch synaptic vesicle transportsearch cellular response to copper ionsearch response to interleukin-1search receptor internalizationsearch response to magnesium ionsearch negative regulation of transporter activitysearch negative regulation of apoptotic processsearch synaptic transmissionsearch protein destabilizationsearch response to interferon-gammasearch response to lipopolysaccharidesearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch regulation of excitatory postsynaptic membrane potentialsearch oxidation-reduction processsearch regulation of macrophage activationsearch calcium ion homeostasissearch response to iron(II) ionsearch regulation of long-term neuronal synaptic plasticitysearch regulation of locomotionsearch neutral lipid metabolic processsearch cellular response to epinephrine stimulussearch negative regulation of microtubule polymerizationsearch regulation of glutamate secretionsearch cell deathsearch mitochondrial membrane organizationsearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch long-term synaptic potentiationsearch positive regulation of receptor recyclingsearch protein bindingsearch tau protein bindingsearch identical protein bindingsearch metal ion bindingsearch protein domain specific bindingsearch alpha-tubulin bindingsearch histone bindingsearch oxidoreductase activitysearch microtubule bindingsearch dynein bindingsearch copper ion bindingsearch calcium ion bindingsearch phospholipase D inhibitor activitysearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch fatty acid bindingsearch magnesium ion bindingsearch kinesin bindingsearch phospholipid bindingsearch ferrous iron bindingsearch phosphoprotein bindingsearch enzyme bindingsearch protein N-terminus bindingsearch phospholipase bindingsearch Hsp70 protein bindingsearch beta-tubulin bindingsearch zinc ion bindingsearch cytoskeletonsearch inclusion bodysearch synaptic vesiclesearch actin cytoskeletonsearch plasma membranesearch nucleussearch cytoplasmsearch extracellular regionsearch growth conesearch axon terminussearch cytoplasmic vesicle membranesearch ribosomesearch perinuclear region of cytoplasmsearch intracellular membrane-bounded organellesearch Golgi apparatussearch membranesearch cytosolsearch nuclear outer membranesearch synapsesearch terminal boutonsearch rough endoplasmic reticulumsearch fibrilsearch cell junctionsearch axonsearch cell cortexsearch platelet alpha granule membranesearch mitochondrionsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch