1xq8 Summary


Human micelle-bound alpha-synuclein

The structure was published by Ulmer, T.S., Bax, A., Cole, N.B., and Nussbaum, R.L., in 2005 in a paper entitled "Structure and dynamics of micelle-bound human alpha-synuclein" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alpha-synuclein. This molecule has the UniProt identifier P37840 (SYUA_HUMAN)search. The sample contained 140 residues which is 100% of the natural sequence. Out of 140 residues 140 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-synuclein P37840 (1-140) (SYUA_HUMAN)search Homo sapienssearch 100% 140 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (1 - 140) Alpha-synuclein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P37840) Synucleinsearch Helix hairpin binsearch PF01387: Synucleinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P37840) cytoplasmsearch nucleussearch membranesearch extracellular regionsearch synaptic vesiclesearch synapsesearch plasma membranesearch lysosomesearch cytosolsearch cell junctionsearch actin cytoskeletonsearch terminal boutonsearch Golgi apparatussearch cytoplasmic vesicle membranesearch fibrilsearch growth conesearch ribosomesearch axonsearch inclusion bodysearch mitochondrionsearch platelet alpha granule membranesearch perinuclear region of cytoplasmsearch intracellular membrane-bounded organellesearch axon terminussearch cytoskeletonsearch nuclear outer membranesearch cell cortexsearch mitochondrial respiratory chain complex Isearch rough endoplasmic reticulumsearch regulation of dopamine secretionsearch cellular response to fibroblast growth factor stimulussearch positive regulation of neurotransmitter secretionsearch negative regulation of apoptotic processsearch calcium ion homeostasissearch negative regulation of monooxygenase activitysearch protein destabilizationsearch synaptic vesicle endocytosissearch regulation of reactive oxygen species biosynthetic processsearch positive regulation of hydrogen peroxide catabolic processsearch cellular response to copper ionsearch positive regulation of inositol phosphate biosynthetic processsearch positive regulation of peptidyl-serine phosphorylationsearch oxidation-reduction processsearch regulation of synaptic vesicle recyclingsearch negative regulation of protein phosphorylationsearch negative regulation of neuron apoptotic processsearch cellular response to oxidative stresssearch synaptic vesicle transportsearch negative regulation of platelet-derived growth factor receptor signaling pathwaysearch negative regulation of serotonin uptakesearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch positive regulation of apoptotic processsearch response to drugsearch synapse organizationsearch negative regulation of histone acetylationsearch negative regulation of norepinephrine uptakesearch negative regulation of thrombin receptor signaling pathwaysearch neutral lipid metabolic processsearch response to cocainesearch response to lipopolysaccharidesearch regulation of long-term neuronal synaptic plasticitysearch positive regulation of endocytosissearch long-term synaptic potentiationsearch regulation of locomotionsearch regulation of neuron deathsearch positive regulation of synaptic transmissionsearch regulation of phospholipase activitysearch response to iron(II) ionsearch regulation of macrophage activationsearch negative regulation of transporter activitysearch regulation of acyl-CoA biosynthetic processsearch adult locomotory behaviorsearch agingsearch synaptic transmissionsearch extracellular fibril organizationsearch negative regulation of transcription from RNA polymerase II promotersearch membrane organizationsearch negative regulation of mitochondrial electron transport, NADH to ubiquinonesearch dopamine biosynthetic processsearch regulation of neurotransmitter secretionsearch mitochondrial ATP synthesis coupled electron transportsearch synaptic transmission, dopaminergicsearch dopamine uptake involved in synaptic transmissionsearch positive regulation of protein serine/threonine kinase activitysearch regulation of reactive oxygen species metabolic processsearch negative regulation of microtubule polymerizationsearch phospholipid metabolic processsearch fatty acid metabolic processsearch response to magnesium ionsearch cellular response to epinephrine stimulussearch regulation of neuronal synaptic plasticitysearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch regulation of excitatory postsynaptic membrane potentialsearch positive regulation of glutathione peroxidase activitysearch negative regulation of dopamine metabolic processsearch response to interferon-gammasearch negative regulation of exocytosissearch response to interleukin-1search microglial cell activationsearch positive regulation of receptor recyclingsearch behavioral response to cocainesearch receptor internalizationsearch mitochondrial membrane organizationsearch regulation of glutamate secretionsearch positive regulation of release of sequestered calcium ion into cytosolsearch negative regulation of dopamine uptake involved in synaptic transmissionsearch dopamine metabolic processsearch kinesin bindingsearch protein bindingsearch tau protein bindingsearch Hsp70 protein bindingsearch beta-tubulin bindingsearch identical protein bindingsearch magnesium ion bindingsearch copper ion bindingsearch phospholipase D inhibitor activitysearch dynein bindingsearch transcription regulatory region DNA bindingsearch phospholipid bindingsearch fatty acid bindingsearch calcium ion bindingsearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch alpha-tubulin bindingsearch zinc ion bindingsearch enzyme bindingsearch histone bindingsearch phosphoprotein bindingsearch protein N-terminus bindingsearch metal ion bindingsearch ferrous iron bindingsearch oxidoreductase activitysearch phospholipase bindingsearch protein domain specific bindingsearch microtubule bindingsearch

Chain InterPro annotation
A Synucleinsearch Alpha-synucleinsearch