1xq7 Summary

pdbe.org/1xq7
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Cyclophilin from Trypanosoma cruzi bound to cyclosporin A

A publication describing this structure is not available. The depositing authors are Caruthers, J.M.search; Hol, W.G.J.search; Structural Genomics of Pathogenic Protozoa Consortium (SGPP)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PEPTIDYL-PROLYL CIS-TRANS ISOMERASE and CYCLOSPORIN A.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Q4DPB9 (30-194) (Q4DPB9_TRYCC)search Trypanosoma cruzi strain CL Brenersearch < 90% 166 100%
B PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Q4DPB9 (30-194) (Q4DPB9_TRYCC)search Trypanosoma cruzi strain CL Brenersearch < 90% 166 100%
C PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Q4DPB9 (30-194) (Q4DPB9_TRYCC)search Trypanosoma cruzi strain CL Brenersearch < 90% 166 100%
D CYCLOSPORIN A Not available
TOLYPOCLADIUM INFLATUM 2search Not available 11 100%
E CYCLOSPORIN A Not available
TOLYPOCLADIUM INFLATUM 2search Not available 11 100%
F CYCLOSPORIN A Not available
TOLYPOCLADIUM INFLATUM 2search Not available 11 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q4DPB9 (30 - 194) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Trypanosoma cruzi

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C Cyclophilin (peptidylprolyl isomerase)search Cyclophilinsearch Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch
D, E, F

Chain Molecule NORINE reference
D, E, FCYCLOSPORIN ANOR00033

Chain ID Biological process (GO) Molecular function (GO)
A, B, C (Q4DPB9) protein foldingsearch protein peptidyl-prolyl isomerizationsearch peptidyl-prolyl cis-trans isomerase activitysearch

Chain InterPro annotation
A, B, C Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch
D, E, F