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EBI PDBe PDBeView

PDBe Entry: 1xpm view

Crystal Structure of Staphylococcus aureus HMG-COA Synthase with HMG-CoA and Acetoacetyl-COA and Acetylated Cysteine
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.6 Å, R-factor: 21.0%, Free R-factor: 22.6%, Spacegroup: P 1 21 1
Released 02/11/2004, deposition: 08/10/2004, last revision: 24/02/2009
Authors Theisen, M.J.search; Misra, I.search; Saadat, D.search; Campobasso, N.search; Miziorko, H.M.search; Harrison, D.H.T.search
Primary citation 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
PROC.NATL.ACAD.SCI.USAsearch vol:47, pag:16442-16447 (2004) [PubMed ID 15498869 ]search
Keywords HMG-COA Synthasesearch, HMGSsearch, Coenzyme Asearch, Thiolase Foldsearch, Condensing Enzymesearch, Cholesterol Biosynthesissearch, TRANSFERASEsearch
Organism Staphylococcus aureus subsp. aureus 46170search(A B C D)
UniProt 3-hydroxy-3-methylglutaryl CoA synthase Q79ZY6search (A B C D)
Solvent A, B, C, D
Related entries 1xpk, 1xpl
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D 3-hydroxy-3-methylglutaryl CoA synthase Protein Q79ZY6 (Q79ZY6_STAAW)search
 396 98%
Heterogens
Id Name Ligands
A, B, C, D SULFATE ION SO4 search
A, B, C, D 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A HMG search
A, B, C, D ACETOACETYL-COENZYME A CAA search
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