1xow Summary


Crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor NH2-terminal peptide, AR20-30, and R1881

The structure was published by He, B., Gampe Jr., R.T., Kole, A.J., et al., Kalman, R.I., Minges, J.T., and Wilson, E.M., in 2004 in a paper entitled "Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely androgen receptor and decamer fragment of androgen receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A androgen receptor P10275 (671-919) (ANDR_HUMAN)search Homo sapienssearch < 90% 249 97%
B decamer fragment of androgen receptor P10275 (20-30) (ANDR_HUMAN)search Homo sapienssearch < 90% 11 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10275 (671 - 919) androgen receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Androgen receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P10275) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch