› 1xow

X-ray diffraction
1.8Å resolution

Crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor NH2-terminal peptide, AR20-30, and R1881

Released:
DOI: 10.2210/pdb1xow/pdb
PDB entry 1xow coloured by chain, front view.
PDB entry 1xow coloured by chain, side view.
PDB entry 1xow coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.
He B, Gampe RT, Kole AJ, Hnat AT, Stanley TB, An G, Stewart EL, Kalman RI, Minges JT, Wilson EM
Mol Cell 16 425-38 (2004)
PMID: 15525515

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145223 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 29.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 672-920; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Androgen receptor Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10275 (Residues: 20-30; Coverage: 1%)
Gene names: AR, DHTR, NR3C4

Ligands and Environments

1 bound ligand:
Ligand R18 1 x R18
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 54.941Å b: 66.118Å c: 70.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.213
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

48 review citations

Chemistry and structural biology of androgen receptor.
Gao et al. (2005)
47 more

15 mentions without citation

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
14 more