1xoe Summary

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N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with

The structure was published by Wang, G.T., Wang, S., Gentles, R., et al., Stoll, V., Stewart, K.D., and Laver, G., in 2005 in a paper entitled "Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Neuraminidase. This molecule has the UniProt identifier P03472 (NRAM_I75A5)search. The sample contained 387 residues which is < 90% of the natural sequence. Out of 387 residues 386 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Neuraminidase P03472 (84-470) (NRAM_I75A5)search Influenza A virus (A/tern/Australia/G70C/1975(H11N9))search < 90% 387 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03472 (84 - 470) Neuraminidase Influenza A virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P03472) carbohydrate metabolic processsearch membranesearch virion membranesearch host cell membranesearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch