1xo2 Summary


Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

The structure was published by Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., and Schulze-Gahmen, U., in 2005 in a paper entitled "Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cyclin and Cell division protein kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cyclin Q01043 (1-254) (CGH2_SHV21)search Herpesvirus saimiri (strain 11)search 90% 254 95%
B Cell division protein kinase 6 Q00534 (1-308) (CDK6_HUMAN)search Homo sapienssearch 92% 308 93%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q01043 (1 - 254) Cyclin Saimiriine herpesvirus 2
Q00534 (1 - 308) Cell division protein kinase 6 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q01043) Cyclinsearch Cyclin A; domain 1search PF00134: Cyclin, N-terminal domainsearch, PF09241: Herpesviridae viral cyclinsearch
B (Q00534) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q01043) cell cyclesearch cell divisionsearch modulation by virus of host cell cyclesearch viral processsearch
B (Q00534) protein phosphorylationsearch cell cyclesearch regulation of cell proliferationsearch cell dedifferentiationsearch G1/S transition of mitotic cell cyclesearch negative regulation of epithelial cell proliferationsearch negative regulation of cell differentiationsearch negative regulation of cell proliferationsearch negative regulation of myeloid cell differentiationsearch regulation of cell motilitysearch positive regulation of cell-matrix adhesionsearch type B pancreatic cell developmentsearch cell cycle arrestsearch regulation of gene expressionsearch response to virussearch cell differentiationsearch dentate gyrus developmentsearch generation of neuronssearch phosphorylationsearch regulation of erythrocyte differentiationsearch negative regulation of cell cyclesearch negative regulation of cellular senescencesearch astrocyte developmentsearch negative regulation of osteoblast differentiationsearch lateral ventricle developmentsearch gliogenesissearch cell divisionsearch positive regulation of fibroblast proliferationsearch mitotic cell cyclesearch protein kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch kinase activitysearch cyclin bindingsearch nucleotide bindingsearch transferase activitysearch nucleussearch cytosolsearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch cell projectionsearch rufflesearch nucleolussearch

Chain InterPro annotation
A Cyclin, N-terminalsearch Cyclin-likesearch Cyclin domain, herpesvirussearch Cyclin, herpesvirussearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Cyclin-dependent kinase 6search