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Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

X-ray diffraction
2.9Å resolution
PDB entry 1xo2 coloured by chain, front view.
PDB entry 1xo2 coloured by chain, side view.
PDB entry 1xo2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent kinase 6 and Cyclin homolog
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Multimeric state: hetero dimer
Accessible surface area: 22511.67 Å2
Buried surface area: 4882.19 Å2
Dissociation area: 2,117.25 Å2
Dissociation energy (ΔGdiss): 20.64 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169440

Macromolecules

Cyclin homolog
Chain: A
Length: 254 amino acids
Theoretical weight: 28.67 KDa
Source organism: Saimiriine gammaherpesvirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01043 (Residues: 1-254; Coverage: 100%)
Gene names: 72, ECLF2
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin homolog in PDB entry 1xo2, assembly 1, front view.
Cyclin homolog in PDB entry 1xo2, assembly 1, side view.
Cyclin homolog in PDB entry 1xo2, assembly 1, top view.
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Cyclin-dependent kinase 6
Chain: B
Length: 308 amino acids
Theoretical weight: 35.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00534 (Residues: 1-308; Coverage: 95%)
Gene names: CDK6, CDKN6
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 6 in PDB entry 1xo2, assembly 1, front view.
Cyclin-dependent kinase 6 in PDB entry 1xo2, assembly 1, side view.
Cyclin-dependent kinase 6 in PDB entry 1xo2, assembly 1, top view.
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