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EBI PDBe PDBeView

PDBe Entry: 1xlz view

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.06 Å, R-factor: 21.04%, Free R-factor: 23.664%, Spacegroup: P 21 21 21
Released 14/12/2004, deposition: 30/09/2004, last revision: 24/02/2009
Authors Card, G.L.search; England, B.P.search; Suzuki, Y.search; Fong, D.search; Powell, B.search; Lee, B.search; Luu, C.search; Tabrizizad, M.search; Gillette, S.search; Ibrahim, P.N.search; Artis, D.R.search; Bollag, G.search; Milburn, M.V.search; Kim, S.-H.search; Schlessinger, J.search; Zhang, K.Y.J.search
Primary citation Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
STRUCTUREsearch vol:12, pag:2233-2247 (2004) [PubMed ID 15576036 ]search
Keywords PDE4Bsearch, Filaminastsearch, HYDROLASEsearch
EC 3.1.4.17 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32) Q07343search (A B)
Solvent A, B
Related entries 1xlx, 1xm4, 1xm6, 1xmu, 1xmy, 1xn0, 1xom, 1xon, 1xoq, 1xor, 1xos, 1xot, 1xoz, 1xp0
Polymers
Id Name Type UniProt Residues Observed
A, B cAMP-specific 3',5'-cyclic phosphodiesterase 4B Protein Q07343 (PDE4B_HUMAN)search
 398 81%
Heterogens
Id Name Ligands
A, B ZINC ION ZN search
A, B MAGNESIUM ION MG search
A, B (1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME FIL search
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