1xk4 Summary

pdbe.org/1xk4
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Crystal structure of human calprotectin(S100A8/S100A9)

A publication describing this structure is not available. The depositing authors are Korndoerfer, I.P.search; Brueckner, F.search; Skerra, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calgranulin A and Calgranulin B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calgranulin A P05109 (1-93) (S10A8_HUMAN)search Homo sapienssearch 100% 93 95%
B Calgranulin A P05109 (1-93) (S10A8_HUMAN)search Homo sapienssearch 100% 93 95%
E Calgranulin A P05109 (1-93) (S10A8_HUMAN)search Homo sapienssearch 100% 93 95%
F Calgranulin A P05109 (1-93) (S10A8_HUMAN)search Homo sapienssearch 100% 93 95%
I Calgranulin A P05109 (1-93) (S10A8_HUMAN)search Homo sapienssearch 100% 93 95%
J Calgranulin A P05109 (1-93) (S10A8_HUMAN)search Homo sapienssearch 100% 93 95%
C Calgranulin B P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 81%
D Calgranulin B P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 81%
G Calgranulin B P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 81%
H Calgranulin B P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 81%
K Calgranulin B P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 81%
L Calgranulin B P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 81%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P05109 (1 - 93) Calgranulin A Homo sapiens
P06702 (2 - 114) Calgranulin B Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, E, F, I, J (P05109) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch
C, D, G, H, K, L (P06702) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, E, F, I, J (P05109) regulation of inflammatory responsesearch chemotaxissearch wound healingsearch neutrophil chemotaxissearch sequestering of zinc ionsearch regulation of cytoskeleton organizationsearch chronic inflammatory responsesearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch inflammatory responsesearch positive regulation of NF-kappaB transcription factor activitysearch innate immune responsesearch leukocyte migration involved in inflammatory responsesearch positive regulation of intrinsic apoptotic signaling pathwaysearch response to zinc ionsearch defense response to bacteriumsearch positive regulation of cell growthsearch chemokine productionsearch response to ethanolsearch acute inflammatory responsesearch immune system processsearch positive regulation of inflammatory responsesearch apoptotic processsearch cytokine productionsearch autophagysearch defense response to fungussearch response to lipopolysaccharidesearch neutrophil aggregationsearch RAGE receptor bindingsearch microtubule bindingsearch calcium ion bindingsearch Toll-like receptor 4 bindingsearch arachidonic acid bindingsearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch extracellular spacesearch extracellular vesicular exosomesearch cytosolsearch membranesearch cytoplasmsearch extracellular regionsearch plasma membranesearch cytoskeletonsearch nucleussearch
C, D, G, H, K, L (P06702) innate immune responsesearch positive regulation of NF-kappaB transcription factor activitysearch defense response to fungussearch positive regulation of inflammatory responsesearch signal transductionsearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch regulation of integrin biosynthetic processsearch positive regulation of intrinsic apoptotic signaling pathwaysearch neutrophil aggregationsearch positive regulation of cell growthsearch neutrophil chemotaxissearch cell-cell signalingsearch actin cytoskeleton reorganizationsearch response to zinc ionsearch response to ethanolsearch autophagysearch sequestering of zinc ionsearch leukocyte chemotaxissearch cytokine productionsearch chronic inflammatory responsesearch inflammatory responsesearch regulation of inflammatory responsesearch leukocyte migration involved in inflammatory responsesearch defense response to bacteriumsearch chemokine productionsearch chemotaxissearch apoptotic processsearch response to lipopolysaccharidesearch immune system processsearch regulation of cytoskeleton organizationsearch arachidonic acid bindingsearch RAGE receptor bindingsearch microtubule bindingsearch calcium ion bindingsearch Toll-like receptor 4 bindingsearch protein bindingsearch zinc ion bindingsearch antioxidant activitysearch signal transducer activitysearch metal ion bindingsearch cytosolsearch cytoskeletonsearch plasma membranesearch extracellular vesicular exosomesearch cytoplasmsearch membranesearch nucleussearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
A, B, E, F, I, J S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-A8search
C, D, G, H, K, L S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-A9search