1xj7 Summary


Complex Androgen Receptor LBD and RAC3 peptide

The structure was published by Estebanez-Perpina, E., Moore, J.M.R., Mar, E., et al., Webb, P., Fletterick, R.J., and Guy, R.K., in 2005 in a paper entitled "The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Androgen receptor and RAC3 derived peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor P10275 (663-919) (ANDR_HUMAN)search Homo sapienssearch < 90% 257 99%
B RAC3 derived peptide Not available
Synthetic Not available 9 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10275 (663 - 919) Androgen receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P10275) nucleussearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch