1xhu Summary

pdbe.org/1xhu
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HincII bound to cleaved, cognate DNA containing GTCGAC

The structure was published by Etzkorn, C. and Horton, N.C., in 2004 in a paper entitled "Mechanistic Insights from the Structures of HincII Bound to Cognate DNA Cleaved from Addition of Mg(2+) and Mn(2+)" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.95 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*GP*CP*CP*GP*GP*TP*C)-3', 5'-D(P*GP*AP*CP*CP*GP*G)-3', and Type II restriction enzyme HincII.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Type II restriction enzyme HincII P17743 (2-258) (T2C2_HAEIF)search Haemophilus influenzaesearch 100% 257 100%
B Type II restriction enzyme HincII P17743 (2-258) (T2C2_HAEIF)search Haemophilus influenzaesearch 100% 257 100%
C Type II restriction enzyme HincII P17743 (2-258) (T2C2_HAEIF)search Haemophilus influenzaesearch 100% 257 100%
D Type II restriction enzyme HincII P17743 (2-258) (T2C2_HAEIF)search Haemophilus influenzaesearch 100% 257 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P17743 (2 - 258) Type II restriction enzyme HincII Haemophilus influenzae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P17743) Restriction endonuclease HincIIsearch ECO RV Endonuclease; Chain Asearch PF09226: Restriction endonuclease HincIIsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (P17743) Type II site-specific deoxyribonuclease activitysearch DNA bindingsearch endonuclease activitysearch hydrolase activitysearch nuclease activitysearch nucleic acid phosphodiester bond hydrolysissearch DNA restriction-modification systemsearch DNA catabolic process, endonucleolyticsearch

Chain InterPro annotation
A, B, C, D Restriction endonuclease type II-likesearch DNA mismatch repair MutH/Restriction endonuclease, type IIsearch Restriction endonuclease, type II, HincIIsearch