1xh7 Summary

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Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

The structure was published by Breitenlechner, C.B., Friebe, W.-G., Brunet, E., et al., Huber, R., Engh, R.A., and Masjost, B., in 2005 in a paper entitled "Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.47 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase, alpha-catalytic subunit and cAMP-dependent protein kinase inhibitor, alpha form.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase, alpha-catalytic subunit P00517 (2-351) (KAPCA_BOVIN)search Bos taurussearch 96% 350 97%
B cAMP-dependent protein kinase inhibitor, alpha form P61925 (6-25) (IPKA_HUMAN)search Homo sapienssearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00517 (2 - 351) cAMP-dependent protein kinase, alpha-catalytic subunit Bos taurus
P61925 (6 - 25) cAMP-dependent protein kinase inhibitor, alpha form

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00517) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
B cAMP-dependent protein kinase inhibitorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00517) protein serine/threonine kinase activitysearch protein kinase bindingsearch protein bindingsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine/tyrosine kinase activitysearch cAMP-dependent protein kinase activitysearch transferase activitysearch ubiquitin protein ligase bindingsearch nucleotide bindingsearch protein kinase A regulatory subunit bindingsearch kinase activitysearch protein phosphorylationsearch peptidyl-serine phosphorylationsearch sperm capacitationsearch mesoderm formationsearch regulation of proteasomal protein catabolic processsearch cellular response to glucose stimulussearch positive regulation of cell cycle arrestsearch regulation of osteoblast differentiationsearch regulation of tight junction assemblysearch positive regulation of protein export from nucleussearch regulation of synaptic transmissionsearch peptidyl-threonine phosphorylationsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch phosphorylationsearch protein autophosphorylationsearch cellular response to parathyroid hormone stimulussearch neural tube closuresearch regulation of protein processingsearch plasma membranesearch cytoplasmsearch mitochondrionsearch membranesearch ciliary basesearch nucleussearch extracellular vesicular exosomesearch neuromuscular junctionsearch sperm midpiecesearch centrosomesearch AMP-activated protein kinase complexsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B cAMP-dependent protein kinase inhibitorsearch