1xfe Summary


Solution structure of the LA7-EGFA pair from the LDL receptor

The structure was published by Beglova, N., Jeon, H., Fisher, C., and Blacklow, S.C., in 2004 in a paper entitled "Cooperation between Fixed and Low pH-Inducible Interfaces Controls Lipoprotein Release by the LDL Receptor" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Low-density lipoprotein receptor. This molecule has the UniProt identifier P01130 (LDLR_HUMAN)search. The sample contained 83 residues which is < 90% of the natural sequence. Out of 83 residues 83 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Low-density lipoprotein receptor P01130 (272-353) (LDLR_HUMAN)search Homo sapienssearch < 90% 83 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01130 (272 - 353) Low-density lipoprotein receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A LDL receptor-like modulesearch, EGF-type modulesearch Low-density Lipoprotein Receptorsearch, Lamininsearch Low-density lipoprotein receptor domain class Asearch

Chain ID Molecular function (GO)
A (P01130) calcium ion bindingsearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Low-density lipoprotein (LDL) receptor class A repeatsearch Low-density lipoprotein (LDL) receptor class A, conserved sitesearch