1xf9 Summary

pdbe.org/1xf9
spacer

Structure of NBD1 from murine CFTR- F508S mutant

The structure was published by Thibodeau, P.H., Brautigam, C.A., Machius, M., and Thomas, P.J., in 2005 in a paper entitled "Side chain and backbone contributions of Phe508 to CFTR folding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Cystic fibrosis transmembrane conductance regulator.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cystic fibrosis transmembrane conductance regulator P26361 (389-670) (CFTR_MOUSE)search Mus musculussearch < 90% 283 93%
B Cystic fibrosis transmembrane conductance regulator P26361 (389-670) (CFTR_MOUSE)search Mus musculussearch < 90% 283 93%
C Cystic fibrosis transmembrane conductance regulator P26361 (389-670) (CFTR_MOUSE)search Mus musculussearch < 90% 283 93%
D Cystic fibrosis transmembrane conductance regulator P26361 (389-670) (CFTR_MOUSE)search Mus musculussearch < 90% 283 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26361 (389 - 670) Cystic fibrosis transmembrane conductance regulator Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D ABC transporter ATPase domain-likesearch P-loop containing nucleotide triphosphate hydrolasessearch ABC transportersearch, Cystic fibrosis TM conductance regulator (CFTR), regulator domainsearch

Chain ID Molecular function (GO)
A, B, C, D (P26361) ATP bindingsearch ATPase activitysearch nucleotide bindingsearch nucleoside-triphosphatase activitysearch

Chain InterPro annotation
A, B, C, D ABC transporter-likesearch AAA+ ATPase domainsearch ABC transporter, conserved sitesearch CFTR regulator domainsearch P-loop containing nucleoside triphosphate hydrolasesearch