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Structure of human aldolase B associated with hereditary fructose intolerance (A149P), at 277K

X-ray diffraction
3Å resolution
PDB entry 1xdl coloured by chain, front view.
PDB entry 1xdl coloured by chain, side view.
PDB entry 1xdl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fructose-bisphosphate aldolase B
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Multimeric state: homo dimer
Accessible surface area: 24773.42 Å2
Buried surface area: 1902.36 Å2
Dissociation area: 838.32 Å2
Dissociation energy (ΔGdiss): 6.6 kcal/mol
Dissociation entropy (TΔSdiss): 13.33 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138348
Assembly 2
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Assembly Name: Fructose-bisphosphate aldolase B
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Multimeric state: homo dimer
Accessible surface area: 25639.32 Å2
Buried surface area: 1865.1 Å2
Dissociation area: 813.5 Å2
Dissociation energy (ΔGdiss): 4.32 kcal/mol
Dissociation entropy (TΔSdiss): 13.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138348
Assembly 3
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Assembly Name: Fructose-bisphosphate aldolase B
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Multimeric state: homo dimer
Accessible surface area: 25194.48 Å2
Buried surface area: 1856.77 Å2
Dissociation area: 800.47 Å2
Dissociation energy (ΔGdiss): 3.63 kcal/mol
Dissociation entropy (TΔSdiss): 13.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138348
Assembly 4
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Assembly Name: Fructose-bisphosphate aldolase B
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Multimeric state: homo dimer
Accessible surface area: 24345.48 Å2
Buried surface area: 1894.47 Å2
Dissociation area: 834.2 Å2
Dissociation energy (ΔGdiss): 7.97 kcal/mol
Dissociation entropy (TΔSdiss): 13.33 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138348

Macromolecules

Fructose-bisphosphate aldolase B
Chains: A, B, C, D, W, X, Y, Z
Length: 365 amino acids
Theoretical weight: 39.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05062 (Residues: 2-364; Coverage: 100%)
Gene names: ALDB, ALDOB
Pfam: Fructose-bisphosphate aldolase class-I
InterPro:
CATH: Aldolase class I
SCOP: Class I aldolase
Fructose-bisphosphate aldolase B in PDB entry 1xdl, assembly 1, front view.
Fructose-bisphosphate aldolase B in PDB entry 1xdl, assembly 1, side view.
Fructose-bisphosphate aldolase B in PDB entry 1xdl, assembly 1, top view.
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