1xbb Summary


Crystal structure of the syk tyrosine kinase domain with Gleevec

The structure was published by Atwell, S., Adams, J.M., Badger, J., et al., Russell, M., Burley, S.K., and Buchanan, S.G., in 2004 in a paper entitled "A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.57 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase SYK. This molecule has the UniProt identifier P43405 (KSYK_HUMAN)search. The sample contained 291 residues which is < 90% of the natural sequence. Out of 291 residues 260 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase SYK P43405 (356-635) (KSYK_HUMAN)search Homo sapienssearch 100% 291 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43405 (356 - 635) Tyrosine-protein kinase SYK Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P43405) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF07714: Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P43405) protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch