1xa6 Summary

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Crystal Structure of the Human Beta2-Chimaerin

The structure was published by Canagarajah, B., Leskow, F.C., Ho, J.Y., et al., Saidi, L.F., Kazanietz, M.G., and Hurley, J.H., in 2004 in a paper entitled "Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Beta2-chimaerin. This molecule has the UniProt identifier P52757 (CHIO_HUMAN)search. The sample contained 466 residues which is 99% of the natural sequence. Out of 466 residues 398 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Beta2-chimaerin P52757 (7-468) (CHIO_HUMAN)search Homo sapienssearch 99% 466 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P52757 (7 - 468) Beta2-chimaerin Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P52757) BCR-homology GTPase activation domain (BH-domain)search, SH2 domainsearch, Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)search SHC Adaptor Proteinsearch, Wheat Germ Agglutinin (Isolectin 2); domain 1search, GTPase -GAP domainsearch PF00017: SH2 domainsearch, PF00130: Phorbol esters/diacylglycerol binding domain (C1 domain)search, PF00620: RhoGAP domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P52757) signal transductionsearch regulation of small GTPase mediated signal transductionsearch positive regulation of GTPase activitysearch small GTPase mediated signal transductionsearch positive regulation of signal transductionsearch intracellular signal transductionsearch SH3/SH2 adaptor activitysearch protein bindingsearch GTPase activator activitysearch metal ion bindingsearch membranesearch cytosolsearch intracellularsearch

Chain InterPro annotation
A Rho GTPase-activating protein domainsearch SH2 domainsearch Protein kinase C-like, phorbol ester/diacylglycerol-binding domainsearch Rho GTPase activation proteinsearch N-chimaerinsearch Diacylglycerol/phorbol-ester bindingsearch