› › Function and Biology

Crystal Structure of the Human Beta2-Chimaerin

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: regulation of small GTPase mediated signal transduction
Cellular component: synapse

Quick links

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00620
Domain description: RhoGAP domain
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of Pfam domain PF00620 (RhoGAP domain) in Beta-chimaerin. Showing 1 copy in chain A.

PF00130
Domain description: Phorbol esters/diacylglycerol binding domain (C1 domain)
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of Pfam domain PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) in Beta-chimaerin. Showing 1 copy in chain A.

PF00017
Domain description: SH2 domain
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of Pfam domain PF00017 (SH2 domain) in Beta-chimaerin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020454
Domain description: Diacylglycerol/phorbol-ester binding
Occurring in:
  1. Beta-chimaerin
IPR000198
Domain description: Rho GTPase-activating protein domain
Occurring in:
  1. Beta-chimaerin
IPR002219
Domain description: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Occurring in:
  1. Beta-chimaerin
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Beta-chimaerin
IPR008936
Domain description: Rho GTPase activation protein
Occurring in:
  1. Beta-chimaerin
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. Beta-chimaerin
IPR037860
Domain description: Chimaerin, RhoGAP domain
Occurring in:
  1. Beta-chimaerin
IPR046349
Domain description: C1-like domain superfamily
Occurring in:
  1. Beta-chimaerin
IPR035840
Domain description: Chimaerin, SH2 domain
Occurring in:
  1. Beta-chimaerin
IPR017356
Domain description: Chimaerin
Occurring in:
  1. Beta-chimaerin

Structure domains

CATH CATH domains
1.10.555.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Phosphatidylinositol 3-kinase; Chain A
Homology: Rho GTPase activation protein
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of CATH domain 1.10.555.10 (Phosphatidylinositol 3-kinase; Chain A) in Beta-chimaerin. Showing 1 copy in chain A.
3.30.60.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of CATH domain 3.30.60.20 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Beta-chimaerin. Showing 1 copy in chain A.
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Beta-chimaerin. Showing 1 copy in chain A.
SCOP SCOP annotations
48351
Class: All alpha proteins
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of SCOP domain 48351 (BCR-homology GTPase activation domain (BH-domain)) in Beta-chimaerin. Showing 1 copy in chain A.
57890
Class: Small proteins
Fold: Cysteine-rich domain
Superfamily: Cysteine-rich domain
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of SCOP domain 57890 (Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)) in Beta-chimaerin. Showing 1 copy in chain A.
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. Beta-chimaerin
The deposited structure of PDB entry 1xa6 contains 1 copy of SCOP domain 55551 (SH2 domain) in Beta-chimaerin. Showing 1 copy in chain A.

Quick links