› 1xa6

X-ray diffraction
3.2Å resolution

Crystal Structure of the Human Beta2-Chimaerin

Released:
DOI: 10.2210/pdb1xa6/pdb
PDB entry 1xa6 coloured by chain, front view.
PDB entry 1xa6 coloured by chain, side view.
PDB entry 1xa6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.
Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH
Cell 119 407-18 (2004)
PMID: 15507211

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156630 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-chimaerin Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 53.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P52757 (Residues: 7-468; Coverage: 99%)
Gene names: ARHGAP3, BCH, CHN2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6122
Unit cell:
a: 131.09Å b: 131.09Å c: 288.75Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.252 0.298
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

GEFs and GAPs: critical elements in the control of small G proteins.
Bos et al. (2007)
18 more

5 mentions without citation

Roots of angiosperm formins: the evolutionary history of plant FH2 domain-containing proteins.
Grunt et al. (2008)
4 more