1x7e Summary

pdbe.org/1x7e
spacer

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH WAY-244

The structure was published by Manas, E.S., Unwalla, R.J., Xu, Z.B., et al., Stahl, M.L., Somers, W.S., and Alvarez, J.C., in 2004 in a paper entitled "Structure-Based Design of Estrogen Receptor-Beta Selective Ligands" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor 1 (alpha) and steroid receptor coactivator-3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor 1 (alpha) P03372 (305-549) (ESR1_HUMAN)search Homo sapienssearch < 90% 245 97%
B Estrogen receptor 1 (alpha) P03372 (305-549) (ESR1_HUMAN)search Homo sapienssearch < 90% 245 97%
C steroid receptor coactivator-3 Not available
Synthetic Not available 13 84%
D steroid receptor coactivator-3 Not available
Synthetic Not available 13 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (305 - 549) Estrogen receptor 1 (alpha) Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P03372) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search