1x76 Summary

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CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697

The structure was published by Manas, E.S., Unwalla, R.J., Xu, Z.B., et al., Stahl, M.L., Somers, W.S., and Alvarez, J.C., in 2004 in a paper entitled "Structure-Based Design of Estrogen Receptor-Beta Selective Ligands" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor beta and STEROID RECEPTOR COACTIVATOR-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor beta Q92731 (261-500) (ESR2_HUMAN)search Homo sapienssearch < 90% 240 93%
B Estrogen receptor beta Q92731 (261-500) (ESR2_HUMAN)search Homo sapienssearch < 90% 240 93%
C STEROID RECEPTOR COACTIVATOR-1 Q15788 (630-640) (NCOA1_HUMAN)search Homo sapienssearch < 90% 13 69%
D STEROID RECEPTOR COACTIVATOR-1 Not available
Synthetic < 90% 13 69%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q92731 (261 - 500) Estrogen receptor beta Homo sapiens
Q15788 (630 - 640) STEROID RECEPTOR COACTIVATOR-1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q92731) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch thyroid hormone receptor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D