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CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697

X-ray diffraction
2.2Å resolution
PDB entry 1x76 coloured by chain, front view.
PDB entry 1x76 coloured by chain, side view.
PDB entry 1x76 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor beta and Nuclear receptor coactivator 1
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Multimeric state: hetero tetramer
Accessible surface area: 19808.68 Å2
Buried surface area: 5498.27 Å2
Dissociation area: 461.32 Å2
Dissociation energy (ΔGdiss): 3.12 kcal/mol
Dissociation entropy (TΔSdiss): 7.23 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172402

Macromolecules

Estrogen receptor beta
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92731 (Residues: 261-500; Coverage: 45%)
Gene names: ESR2, ESTRB, NR3A2
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Estrogen receptor beta in PDB entry 1x76, assembly 1, front view.
Estrogen receptor beta in PDB entry 1x76, assembly 1, side view.
Estrogen receptor beta in PDB entry 1x76, assembly 1, top view.
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Nuclear receptor coactivator 1
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 630-640; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1
Nuclear receptor coactivator 1 in PDB entry 1x76, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 1x76, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 1x76, assembly 1, top view.
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