1x27 Summary

pdbe.org/1x27
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Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas

The structure was published by Nasertorabi, F., Tars, K., Becherer, K., et al., Liljas, L., Vuori, K., and Ely, K.R., in 2006 in a paper entitled "Molecular basis for regulation of Src by the docking protein p130Cas" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Proto-oncogene tyrosine-protein kinase LCK and CRK-associated substrate.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase LCK P06239 (64-226) (LCK_HUMAN)search Homo sapienssearch < 90% 167 98%
B Proto-oncogene tyrosine-protein kinase LCK P06239 (64-226) (LCK_HUMAN)search Homo sapienssearch < 90% 167 98%
C Proto-oncogene tyrosine-protein kinase LCK P06239 (64-226) (LCK_HUMAN)search Homo sapienssearch < 90% 167 98%
D Proto-oncogene tyrosine-protein kinase LCK P06239 (64-226) (LCK_HUMAN)search Homo sapienssearch < 90% 167 98%
E Proto-oncogene tyrosine-protein kinase LCK P06239 (64-226) (LCK_HUMAN)search Homo sapienssearch < 90% 167 98%
F Proto-oncogene tyrosine-protein kinase LCK P06239 (64-226) (LCK_HUMAN)search Homo sapienssearch < 90% 167 98%
I CRK-associated substrate Q63767 (759-767) (BCAR1_RAT)search Rattus norvegicussearch < 90% 9 66%
J CRK-associated substrate Q63767 (759-767) (BCAR1_RAT)search Rattus norvegicussearch < 90% 9 66%
K CRK-associated substrate Q63767 (759-767) (BCAR1_RAT)search Rattus norvegicussearch < 90% 9 66%
L CRK-associated substrate Q63767 (759-767) (BCAR1_RAT)search Rattus norvegicussearch < 90% 9 66%
M CRK-associated substrate Q63767 (759-767) (BCAR1_RAT)search Rattus norvegicussearch < 90% 9 66%
N CRK-associated substrate Q63767 (759-767) (BCAR1_RAT)search Rattus norvegicussearch < 90% 9 66%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06239 (64 - 226) Proto-oncogene tyrosine-protein kinase LCK Homo sapiens
Q63767 (759 - 767) CRK-associated substrate

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F SH3-domainsearch, SH2 domainsearch SH3 Domainssearch, SHC Adaptor Proteinsearch SH2 domainsearch, SH3 domainsearch
I, J, K, L, M, N Domain of unknown function (DUF3513)search
Chain InterPro annotation
A, B, C, D, E, F SH2 domainsearch SH3 domainsearch
I, J, K, L, M, N