Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134068 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-nerve growth factor
Molecule details ›
Chains: V, W
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P01138 (Residues: 122-241; Coverage: 54%)
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
High affinity nerve growth factor receptor
Molecule details ›
Chains: X, Y
Length: 101 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Structure domains: Immunoglobulins
Length: 101 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P04629 (Residues: 282-382; Coverage: 13%)
Structure domains: Immunoglobulins
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 5.0.2
Spacegroup:
P21
Expression system: Escherichia coli
